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KMID : 1101420150470040259
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Korean Journal of Clinical Laboratory Science
2015 Volume.47 No. 4 p.259 ~ p.266
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Human Papillomavirus Prevalence and Distribution according to Age among Korean and Chinese Women
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Kim Gee-Hyuk
Kim Sung-Hyun
Park Sun-Young
Park Sang-Jung
Lin Han
Ren Yubo
Yingxue Li
Lee In-Soo
Lee Jae-Dal
Lee Dong-Sup
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Abstract
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Cervical cancer is the third most common cancer among women worldwide. Cervical cancer is significantly associated with human papillomavirus (HPV) infection. The prevalence of HPV infection is influenced by geography, immune status, sexual history and genetic factors. For example, geographically, HPV prevalence varies from 1.5% to 39%. However, little is known about the relationship between HPV prevalence and age. An analysis of HPV prevalence by age will help determine when high-risk groups are exposed to HPV. Such an analysis could also demonstrate a correlation between specific HPV genotypes and age. In addition, the analysis might clarify the optimum age for using vaccines. In this study, HPV prevalence and genotype distribution among Korean and Chinese women are analyzed by age. The REBA HPV-ID? assay (YD diagnostics, Yong-in, Republic of Korea) was used for detecting HPV genotypes in uterine cervical liquid-based cytology samples from 533 women from Korea and 324 from East China (Western Shandong province. Women with severe dysplasia such as SCC (Squamous cell carcinoma) and HSIL (High-grade squamous intraepithelial lesion) groups were primarily in their 40s and 50s, whereas women with mild and moderate dysplasia (ASCUS and LSIL groups) were primarily in their 30s and 40s. Women with HPV genotype 16 and 18 infections were primarily in their 40s. The results suggest that HPV infection is associated with certain age groups in the Korean population.
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KEYWORD
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Human papillomavirus, DNA genotyping, China, Korea, Age
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